Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts
Identifieur interne : 001C01 ( Main/Exploration ); précédent : 001C00; suivant : 001C02Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts
Auteurs : Cécile Troupin [France] ; Laurent Dacheux [France] ; Marion Tanguy [France] ; Claude Sabeta [Afrique du Sud] ; Hervé Blanc [France] ; Christiane Bouchier [France] ; Marco Vignuzzi [France] ; Sebastián Duchene [Australie] ; Edward C. Holmes [Australie] ; Hervé Bourhy [France]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Animaux sauvages (virologie), Carnivora, Génome viral, Humains, Interactions hôte-pathogène (physiologie), Phylogénie, RT-PCR, Rage (maladie) (médecine vétérinaire), Séquençage nucléotidique à haut débit, Virus de la rage (génétique), Zoonoses (transmission), Évolution biologique.
- MESH :
- génétique : ARN viral, Virus de la rage.
- médecine vétérinaire : Rage (maladie).
- physiologie : Interactions hôte-pathogène.
- virologie : Animaux sauvages.
- transmission : Animaux, Carnivora, Génome viral, Humains, Phylogénie, RT-PCR, Séquençage nucléotidique à haut débit, Zoonoses, Évolution biologique.
English descriptors
- KwdEn :
- Animals, Animals, Wild (virology), Biological Evolution, Carnivora, Genome, Viral, High-Throughput Nucleotide Sequencing, Host-Pathogen Interactions (physiology), Humans, Phylogeny, RNA, Viral (genetics), Rabies (veterinary), Rabies virus (genetics), Reverse Transcriptase Polymerase Chain Reaction, Zoonoses (transmission).
- MESH :
- chemical , genetics : RNA, Viral.
- genetics : Rabies virus.
- physiology : Host-Pathogen Interactions.
- transmission : Zoonoses.
- veterinary : Rabies.
- virology : Animals, Wild.
- Animals, Biological Evolution, Carnivora, Genome, Viral, High-Throughput Nucleotide Sequencing, Humans, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that underpin viral emergence. Using 321 genome sequences spanning an unprecedented diversity of RABV, we compared evolutionary rates and selection pressures in viruses sampled from multiple primary host shifts that occurred on various continents. Two major phylogenetic groups, bat-related RABV and dog-related RABV, experiencing markedly different evolutionary dynamics were identified. While no correlation between time and genetic divergence was found in bat-related RABV, the evolution of dog-related RABV followed a generally clock-like structure, although with a relatively low evolutionary rate. Subsequent molecular clock dating indicated that dog-related RABV likely underwent a rapid global spread following the intensification of intercontinental trade starting in the 15th century. Strikingly, although dog RABV has jumped to various wildlife species from the order
Url:
DOI: 10.1371/journal.ppat.1006041
PubMed: 27977811
PubMed Central: 5158080
Affiliations:
- Afrique du Sud, Australie, France
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Melbourne, Université de Sydney
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Le document en format XML
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on Rabies, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institut Pasteur, Genomics Platform, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Genomics Platform, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sabeta, Claude" sort="Sabeta, Claude" uniqKey="Sabeta C" first="Claude" last="Sabeta">Claude Sabeta</name><affiliation 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type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dacheux, Laurent" sort="Dacheux, Laurent" uniqKey="Dacheux L" first="Laurent" last="Dacheux">Laurent Dacheux</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tanguy, Marion" sort="Tanguy, Marion" uniqKey="Tanguy M" first="Marion" last="Tanguy">Marion Tanguy</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institut Pasteur, Genomics Platform, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Genomics Platform, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sabeta, Claude" sort="Sabeta, Claude" uniqKey="Sabeta C" first="Claude" last="Sabeta">Claude Sabeta</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Agricultural Research Council, Onderstepoort Veterinary Institute, OIE Rabies Reference Laboratory, Pretoria, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Agricultural Research Council, Onderstepoort Veterinary Institute, OIE Rabies Reference Laboratory, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Blanc, Herve" sort="Blanc, Herve" uniqKey="Blanc H" first="Hervé" last="Blanc">Hervé Blanc</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Institut Pasteur, Centre National de la Recherche Scientifique UMR 3569, Viral Populations and Pathogenesis Unit, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Centre National de la Recherche Scientifique UMR 3569, Viral Populations and Pathogenesis Unit, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institut Pasteur, Genomics Platform, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Genomics Platform, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vignuzzi, Marco" sort="Vignuzzi, Marco" uniqKey="Vignuzzi M" first="Marco" last="Vignuzzi">Marco Vignuzzi</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Institut Pasteur, Centre National de la Recherche Scientifique UMR 3569, Viral Populations and Pathogenesis Unit, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Centre National de la Recherche Scientifique UMR 3569, Viral Populations and Pathogenesis Unit, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duchene, Sebastian" sort="Duchene, Sebastian" uniqKey="Duchene S" first="Sebastián" last="Duchene">Sebastián Duchene</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff006"><addr-line>Centre for Systems Genomics, University of Melbourne, Parkville, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Systems Genomics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Bourhy, Herve" sort="Bourhy, Herve" uniqKey="Bourhy H" first="Hervé" last="Bourhy">Hervé Bourhy</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Wild (virology)</term><term>Biological Evolution</term><term>Carnivora</term><term>Genome, Viral</term><term>High-Throughput Nucleotide Sequencing</term><term>Host-Pathogen Interactions (physiology)</term><term>Humans</term><term>Phylogeny</term><term>RNA, Viral (genetics)</term><term>Rabies (veterinary)</term><term>Rabies virus (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Zoonoses (transmission)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Animaux</term><term>Animaux sauvages (virologie)</term><term>Carnivora</term><term>Génome viral</term><term>Humains</term><term>Interactions hôte-pathogène (physiologie)</term><term>Phylogénie</term><term>RT-PCR</term><term>Rage (maladie) (médecine vétérinaire)</term><term>Séquençage nucléotidique à haut débit</term><term>Virus de la rage (génétique)</term><term>Zoonoses (transmission)</term><term>Évolution biologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus de la rage</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Rage (maladie)</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Interactions hôte-pathogène</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Host-Pathogen Interactions</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Animaux sauvages</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animals, Wild</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Carnivora</term><term>Genome, Viral</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Phylogeny</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term><term>Carnivora</term><term>Génome viral</term><term>Humains</term><term>Phylogénie</term><term>RT-PCR</term><term>Séquençage nucléotidique à haut débit</term><term>Zoonoses</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that underpin viral emergence. Using 321 genome sequences spanning an unprecedented diversity of RABV, we compared evolutionary rates and selection pressures in viruses sampled from multiple primary host shifts that occurred on various continents. Two major phylogenetic groups, bat-related RABV and dog-related RABV, experiencing markedly different evolutionary dynamics were identified. While no correlation between time and genetic divergence was found in bat-related RABV, the evolution of dog-related RABV followed a generally clock-like structure, although with a relatively low evolutionary rate. Subsequent molecular clock dating indicated that dog-related RABV likely underwent a rapid global spread following the intensification of intercontinental trade starting in the 15<sup>th</sup> century. Strikingly, although dog RABV has jumped to various wildlife species from the order <italic>Carnivora</italic>, we found no clear evidence that these host-jumping events involved adaptive evolution, with RABV instead characterized by strong purifying selection, suggesting that ecological processes also play an important role in shaping patterns of emergence. However, specific amino acid changes were associated with the parallel emergence of RABV in ferret-badgers in Asia, and some host shifts were associated with increases in evolutionary rate, particularly in the ferret-badger and mongoose, implying that changes in host species can have important impacts on evolutionary dynamics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author><author><name sortKey="Rimmelzwaan, G" uniqKey="Rimmelzwaan G">G Rimmelzwaan</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cleaveland, S" uniqKey="Cleaveland S">S Cleaveland</name></author><author><name sortKey="Haydon, Dt" uniqKey="Haydon D">DT Haydon</name></author><author><name sortKey="Taylor, L" uniqKey="Taylor L">L Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cleaveland, S" uniqKey="Cleaveland S">S Cleaveland</name></author><author><name sortKey="Laurenson, Mk" uniqKey="Laurenson M">MK Laurenson</name></author><author><name sortKey="Taylor, Lh" uniqKey="Taylor L">LH Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Childs, Je" uniqKey="Childs J">JE Childs</name></author><author><name sortKey="Richt, Ja" uniqKey="Richt J">JA Richt</name></author><author><name sortKey="Mackenzie, Js" uniqKey="Mackenzie J">JS Mackenzie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Steinhauer, Da" uniqKey="Steinhauer D">DA Steinhauer</name></author><author><name sortKey="Holland, Jj" uniqKey="Holland J">JJ Holland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Badrane, H" uniqKey="Badrane H">H Badrane</name></author><author><name sortKey="Tordo, N" uniqKey="Tordo N">N Tordo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faria, Nr" uniqKey="Faria N">NR Faria</name></author><author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Streicker, Dg" uniqKey="Streicker D">DG Streicker</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Woelk, Ch" uniqKey="Woelk C">CH Woelk</name></author><author><name sortKey="Kassis, R" uniqKey="Kassis R">R Kassis</name></author><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H Bourhy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author><author><name sortKey="Turmelle, A" uniqKey="Turmelle A">A Turmelle</name></author><author><name sortKey="Kuzmin, Iv" uniqKey="Kuzmin I">IV Kuzmin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nel, Lh" uniqKey="Nel L">LH Nel</name></author><author><name sortKey="Markotter, W" uniqKey="Markotter W">W Markotter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H Bourhy</name></author><author><name sortKey="Reynes, Jm" uniqKey="Reynes J">JM Reynes</name></author><author><name sortKey="Dunham, Ej" uniqKey="Dunham E">EJ Dunham</name></author><author><name sortKey="Dacheux, L" uniqKey="Dacheux L">L Dacheux</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author><author><name sortKey="Huong, Vt" uniqKey="Huong V">VT Huong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuzmin, Iv" uniqKey="Kuzmin I">IV Kuzmin</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Orciari, La" uniqKey="Orciari L">LA Orciari</name></author><author><name sortKey="Yager, Pa" uniqKey="Yager P">PA Yager</name></author><author><name sortKey="Velasco Villa, A" uniqKey="Velasco Villa A">A Velasco-Villa</name></author><author><name sortKey="Kuzmina, Na" uniqKey="Kuzmina N">NA Kuzmina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biek, R" uniqKey="Biek R">R Biek</name></author><author><name sortKey="Henderson, Jc" uniqKey="Henderson J">JC Henderson</name></author><author><name sortKey="Waller, La" uniqKey="Waller L">LA Waller</name></author><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author><author><name sortKey="Real, La" uniqKey="Real L">LA Real</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, R" uniqKey="Davis R">R Davis</name></author><author><name sortKey="Nadin Davis, Sa" uniqKey="Nadin Davis S">SA Nadin-Davis</name></author><author><name sortKey="Moore, M" uniqKey="Moore M">M Moore</name></author><author><name sortKey="Hanlon, C" uniqKey="Hanlon C">C Hanlon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuzmina, Na" uniqKey="Kuzmina N">NA Kuzmina</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author><author><name sortKey="Kuzmin, Iv" uniqKey="Kuzmin I">IV Kuzmin</name></author><author><name sortKey="Mayes, Bc" uniqKey="Mayes B">BC Mayes</name></author><author><name sortKey="Ellison, Ja" uniqKey="Ellison J">JA Ellison</name></author><author><name sortKey="Orciari, La" uniqKey="Orciari L">LA Orciari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H Bourhy</name></author><author><name sortKey="Kissi, B" uniqKey="Kissi B">B Kissi</name></author><author><name sortKey="Audry, L" uniqKey="Audry L">L Audry</name></author><author><name sortKey="Smreczak, M" uniqKey="Smreczak M">M Smreczak</name></author><author><name sortKey="Sadkowska Todys, M" uniqKey="Sadkowska Todys M">M Sadkowska-Todys</name></author><author><name sortKey="Kulonen, K" uniqKey="Kulonen K">K Kulonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nel, Lh" uniqKey="Nel L">LH Nel</name></author><author><name sortKey="Sabeta, Ct" uniqKey="Sabeta C">CT Sabeta</name></author><author><name sortKey="Von Teichman, B" uniqKey="Von Teichman B">B von Teichman</name></author><author><name sortKey="Jaftha, Jb" uniqKey="Jaftha J">JB Jaftha</name></author><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author><author><name sortKey="Bingham, J" uniqKey="Bingham J">J Bingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oem, Jk" uniqKey="Oem J">JK Oem</name></author><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name></author><author><name sortKey="Kim, Yh" uniqKey="Kim Y">YH Kim</name></author><author><name sortKey="Lee, Mh" uniqKey="Lee M">MH Lee</name></author><author><name sortKey="Lee, Kk" uniqKey="Lee K">KK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Kj" uniqKey="Tsai K">KJ Tsai</name></author><author><name sortKey="Hsu, Wc" uniqKey="Hsu W">WC Hsu</name></author><author><name sortKey="Chuang, Wc" uniqKey="Chuang W">WC Chuang</name></author><author><name sortKey="Chang, Jc" uniqKey="Chang J">JC Chang</name></author><author><name sortKey="Tu, Yc" uniqKey="Tu Y">YC Tu</name></author><author><name sortKey="Tsai, Hj" uniqKey="Tsai H">HJ Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Mi, L" uniqKey="Mi L">L Mi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hampson, K" uniqKey="Hampson K">K Hampson</name></author><author><name sortKey="Coudeville, L" uniqKey="Coudeville L">L Coudeville</name></author><author><name sortKey="Lembo, T" uniqKey="Lembo T">T Lembo</name></author><author><name sortKey="Sambo, M" uniqKey="Sambo M">M Sambo</name></author><author><name sortKey="Kieffer, A" uniqKey="Kieffer A">A Kieffer</name></author><author><name sortKey="Attlan, M" uniqKey="Attlan M">M Attlan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nadin Davis, Sa" uniqKey="Nadin Davis S">SA Nadin-Davis</name></author><author><name sortKey="Abdel Malik, M" uniqKey="Abdel Malik M">M Abdel-Malik</name></author><author><name sortKey="Armstrong, J" uniqKey="Armstrong J">J Armstrong</name></author><author><name sortKey="Wandeler, Ai" uniqKey="Wandeler A">AI Wandeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pant, Gr" uniqKey="Pant G">GR Pant</name></author><author><name sortKey="Lavenir, R" uniqKey="Lavenir R">R Lavenir</name></author><author><name sortKey="Wong, Fy" uniqKey="Wong F">FY Wong</name></author><author><name sortKey="Certoma, A" uniqKey="Certoma A">A Certoma</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author><author><name sortKey="Bhatta, Dr" uniqKey="Bhatta D">DR Bhatta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Streicker, Dg" uniqKey="Streicker D">DG Streicker</name></author><author><name sortKey="Altizer, Sm" uniqKey="Altizer S">SM Altizer</name></author><author><name sortKey="Velasco Villa, A" uniqKey="Velasco Villa A">A Velasco-Villa</name></author><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Talbi, C" uniqKey="Talbi C">C Talbi</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="De Benedictis, P" uniqKey="De Benedictis P">P de Benedictis</name></author><author><name sortKey="Faye, O" uniqKey="Faye O">O Faye</name></author><author><name sortKey="Nakoune, E" uniqKey="Nakoune E">E Nakoune</name></author><author><name sortKey="Gamatie, D" uniqKey="Gamatie D">D Gamatie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Hu, R" uniqKey="Hu R">R Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zieger, U" uniqKey="Zieger U">U Zieger</name></author><author><name sortKey="Marston, Da" uniqKey="Marston D">DA Marston</name></author><author><name sortKey="Sharma, R" uniqKey="Sharma R">R Sharma</name></author><author><name sortKey="Chikweto, A" uniqKey="Chikweto A">A Chikweto</name></author><author><name sortKey="Tiwari, K" uniqKey="Tiwari K">K Tiwari</name></author><author><name sortKey="Sayyid, M" uniqKey="Sayyid M">M Sayyid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunker, K" uniqKey="Brunker K">K Brunker</name></author><author><name sortKey="Marston, Da" uniqKey="Marston D">DA Marston</name></author><author><name sortKey="Horton, Dl" uniqKey="Horton D">DL Horton</name></author><author><name sortKey="Cleaveland, S" uniqKey="Cleaveland S">S Cleaveland</name></author><author><name sortKey="Fooks, Ar" uniqKey="Fooks A">AR Fooks</name></author><author><name sortKey="Kazwala, R" uniqKey="Kazwala R">R Kazwala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delmas, O" uniqKey="Delmas O">O Delmas</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Talbi, C" uniqKey="Talbi C">C Talbi</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author><author><name sortKey="Dacheux, L" uniqKey="Dacheux L">L Dacheux</name></author><author><name sortKey="Bouchier, C" uniqKey="Bouchier C">C Bouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Hb" uniqKey="Tang H">HB Tang</name></author><author><name sortKey="Lu, Zl" uniqKey="Lu Z">ZL Lu</name></author><author><name sortKey="Zhong, Yz" uniqKey="Zhong Y">YZ Zhong</name></author><author><name sortKey="He, Xx" uniqKey="He X">XX He</name></author><author><name sortKey="Zhong, Tz" uniqKey="Zhong T">TZ Zhong</name></author><author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Zhang, Hl" uniqKey="Zhang H">HL Zhang</name></author><author><name sortKey="Tao, Xy" uniqKey="Tao X">XY Tao</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Tang, Q" uniqKey="Tang Q">Q Tang</name></author><author><name sortKey="Jiang, Xy" uniqKey="Jiang X">XY Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Talbi, C" uniqKey="Talbi C">C Talbi</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author><author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name></author><author><name sortKey="Abdelatif, E" uniqKey="Abdelatif E">E Abdelatif</name></author><author><name sortKey="Elharrak, M" uniqKey="Elharrak M">M Elharrak</name></author><author><name sortKey="Nourlil, J" uniqKey="Nourlil J">J Nourlil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H Bourhy</name></author><author><name sortKey="Nakoune, E" uniqKey="Nakoune E">E Nakoune</name></author><author><name sortKey="Hall, M" uniqKey="Hall M">M Hall</name></author><author><name sortKey="Nouvellet, P" uniqKey="Nouvellet P">P Nouvellet</name></author><author><name sortKey="Lepelletier, A" uniqKey="Lepelletier A">A Lepelletier</name></author><author><name sortKey="Talbi, C" uniqKey="Talbi C">C Talbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Streicker, Dg" uniqKey="Streicker D">DG Streicker</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author><author><name sortKey="Velasco Villa, A" uniqKey="Velasco Villa A">A Velasco-Villa</name></author><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fourment, M" uniqKey="Fourment M">M Fourment</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fooks, Ar" uniqKey="Fooks A">AR Fooks</name></author><author><name sortKey="Banyard, Ac" uniqKey="Banyard A">AC Banyard</name></author><author><name sortKey="Horton, Dl" uniqKey="Horton D">DL Horton</name></author><author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name></author><author><name sortKey="Mcelhinney, Lm" uniqKey="Mcelhinney L">LM McElhinney</name></author><author><name sortKey="Jackson, Ac" uniqKey="Jackson A">AC Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Velasco Villa, A" uniqKey="Velasco Villa A">A Velasco-Villa</name></author><author><name sortKey="Orciari, La" uniqKey="Orciari L">LA Orciari</name></author><author><name sortKey="Souza, V" uniqKey="Souza V">V Souza</name></author><author><name sortKey="Juarez Islas, V" uniqKey="Juarez Islas V">V Juarez-Islas</name></author><author><name sortKey="Gomez Sierra, M" uniqKey="Gomez Sierra M">M Gomez-Sierra</name></author><author><name sortKey="Castillo, A" uniqKey="Castillo A">A Castillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Jc" uniqKey="Chang J">JC Chang</name></author><author><name sortKey="Tsai, Kj" uniqKey="Tsai K">KJ Tsai</name></author><author><name sortKey="Hsu, Wc" uniqKey="Hsu W">WC Hsu</name></author><author><name sortKey="Tu, Yc" uniqKey="Tu Y">YC Tu</name></author><author><name sortKey="Chuang, Wc" uniqKey="Chuang W">WC Chuang</name></author><author><name sortKey="Chang, Cy" uniqKey="Chang C">CY Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiou, Hy" uniqKey="Chiou H">HY Chiou</name></author><author><name sortKey="Hsieh, Ch" uniqKey="Hsieh C">CH Hsieh</name></author><author><name sortKey="Jeng, Cr" uniqKey="Jeng C">CR Jeng</name></author><author><name sortKey="Chan, Ft" uniqKey="Chan F">FT Chan</name></author><author><name sortKey="Wang, Hy" uniqKey="Wang H">HY Wang</name></author><author><name sortKey="Pang, Vf" uniqKey="Pang V">VF Pang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, Pl" uniqKey="Davis P">PL Davis</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H Bourhy</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Zyl, N" uniqKey="Van Zyl N">N Van Zyl</name></author><author><name sortKey="Markotter, W" uniqKey="Markotter W">W Markotter</name></author><author><name sortKey="Nel, Lh" uniqKey="Nel L">LH Nel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, W" uniqKey="Gong W">W Gong</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Za, Y" uniqKey="Za Y">Y Za</name></author><author><name sortKey="Zeng, Z" uniqKey="Zeng Z">Z Zeng</name></author><author><name sortKey="Shao, M" uniqKey="Shao M">M Shao</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapiro, B" uniqKey="Shapiro B">B Shapiro</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name></author><author><name sortKey="Kitchen, Cm" uniqKey="Kitchen C">CM Kitchen</name></author><author><name sortKey="Sinsheimer, Js" uniqKey="Sinsheimer J">JS Sinsheimer</name></author><author><name sortKey="Weiss, Re" uniqKey="Weiss R">RE Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, B" uniqKey="Murrell B">B Murrell</name></author><author><name sortKey="Moola, S" uniqKey="Moola S">S Moola</name></author><author><name sortKey="Mabona, A" uniqKey="Mabona A">A Mabona</name></author><author><name sortKey="Weighill, T" uniqKey="Weighill T">T Weighill</name></author><author><name sortKey="Sheward, D" uniqKey="Sheward D">D Sheward</name></author><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, B" uniqKey="Murrell B">B Murrell</name></author><author><name sortKey="Wertheim, Jo" uniqKey="Wertheim J">JO Wertheim</name></author><author><name sortKey="Moola, S" uniqKey="Moola S">S Moola</name></author><author><name sortKey="Weighill, T" uniqKey="Weighill T">T Weighill</name></author><author><name sortKey="Scheffler, K" uniqKey="Scheffler K">K Scheffler</name></author><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Yin, C" uniqKey="Yin C">C Yin</name></author><author><name sortKey="Han, N" uniqKey="Han N">N Han</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meng, S" uniqKey="Meng S">S Meng</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Xu, G" uniqKey="Xu G">G Xu</name></author><author><name sortKey="Lei, Y" uniqKey="Lei Y">Y Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ming, P" uniqKey="Ming P">P Ming</name></author><author><name sortKey="Du, J" uniqKey="Du J">J Du</name></author><author><name sortKey="Tang, Q" uniqKey="Tang Q">Q Tang</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Nadin Davis, Sa" uniqKey="Nadin Davis S">SA Nadin-Davis</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Rayner, S" uniqKey="Rayner S">S Rayner</name></author><author><name sortKey="Liang, G" uniqKey="Liang G">G Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertheim, Jo" uniqKey="Wertheim J">JO Wertheim</name></author><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assenberg, R" uniqKey="Assenberg R">R Assenberg</name></author><author><name sortKey="Delmas, O" uniqKey="Delmas O">O Delmas</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author><author><name sortKey="Vidalain, Po" uniqKey="Vidalain P">PO Vidalain</name></author><author><name sortKey="Verma, A" uniqKey="Verma A">A Verma</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavrakis, M" uniqKey="Mavrakis M">M Mavrakis</name></author><author><name sortKey="Mccarthy, Aa" uniqKey="Mccarthy A">AA McCarthy</name></author><author><name sortKey="Roche, S" uniqKey="Roche S">S Roche</name></author><author><name sortKey="Blondel, D" uniqKey="Blondel D">D Blondel</name></author><author><name sortKey="Ruigrok, Rw" uniqKey="Ruigrok R">RW Ruigrok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steele, Jh" uniqKey="Steele J">JH Steele</name></author><author><name sortKey="Fernandez, Pj" uniqKey="Fernandez P">PJ Fernandez</name></author><author><name sortKey="Baer, Gm" uniqKey="Baer G">GM Baer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theodorides, J" uniqKey="Theodorides J">J Theodorides</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Streicker, Dg" uniqKey="Streicker D">DG Streicker</name></author><author><name sortKey="Turmelle, As" uniqKey="Turmelle A">AS Turmelle</name></author><author><name sortKey="Vonhof, Mj" uniqKey="Vonhof M">MJ Vonhof</name></author><author><name sortKey="Kuzmin, Iv" uniqKey="Kuzmin I">IV Kuzmin</name></author><author><name sortKey="Mccracken, Gf" uniqKey="Mccracken G">GF McCracken</name></author><author><name sortKey="Rupprecht, Ce" uniqKey="Rupprecht C">CE Rupprecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villarreal, Lp" uniqKey="Villarreal L">LP Villarreal</name></author><author><name sortKey="Defilippis, Vr" uniqKey="Defilippis V">VR Defilippis</name></author><author><name sortKey="Gottlieb, Ka" uniqKey="Gottlieb K">KA Gottlieb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engeman, Rm" uniqKey="Engeman R">RM Engeman</name></author><author><name sortKey="Christensen, Kl" uniqKey="Christensen K">KL Christensen</name></author><author><name sortKey="Pipas, Mj" uniqKey="Pipas M">MJ Pipas</name></author><author><name sortKey="Bergman, Dl" uniqKey="Bergman D">DL Bergman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leslie, Mj" uniqKey="Leslie M">MJ Leslie</name></author><author><name sortKey="Messenger, S" uniqKey="Messenger S">S Messenger</name></author><author><name sortKey="Rohde, Re" uniqKey="Rohde R">RE Rohde</name></author><author><name sortKey="Smith, J" uniqKey="Smith J">J Smith</name></author><author><name sortKey="Cheshier, R" uniqKey="Cheshier R">R Cheshier</name></author><author><name sortKey="Hanlon, C" uniqKey="Hanlon C">C Hanlon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mollentze, N" uniqKey="Mollentze N">N Mollentze</name></author><author><name sortKey="Biek, R" uniqKey="Biek R">R Biek</name></author><author><name sortKey="Streicker, Dg" uniqKey="Streicker D">DG Streicker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borucki, Mk" uniqKey="Borucki M">MK Borucki</name></author><author><name sortKey="Chen Harris, H" uniqKey="Chen Harris H">H Chen-Harris</name></author><author><name sortKey="Lao, V" uniqKey="Lao V">V Lao</name></author><author><name sortKey="Vanier, G" uniqKey="Vanier G">G Vanier</name></author><author><name sortKey="Wadford, Da" uniqKey="Wadford D">DA Wadford</name></author><author><name sortKey="Messenger, S" uniqKey="Messenger S">S Messenger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Park, Ec" uniqKey="Park E">EC Park</name></author><author><name sortKey="Burke, Ds" uniqKey="Burke D">DS Burke</name></author><author><name sortKey="Calisher, Ch" uniqKey="Calisher C">CH Calisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woolhouse, Me" uniqKey="Woolhouse M">ME Woolhouse</name></author><author><name sortKey="Haydon, Dt" uniqKey="Haydon D">DT Haydon</name></author><author><name sortKey="Antia, R" uniqKey="Antia R">R Antia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanjuan, R" uniqKey="Sanjuan R">R Sanjuan</name></author><author><name sortKey="Cuevas, Jm" uniqKey="Cuevas J">JM Cuevas</name></author><author><name sortKey="Moya, A" uniqKey="Moya A">A Moya</name></author><author><name sortKey="Elena, Sf" uniqKey="Elena S">SF Elena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiltzer, L" uniqKey="Wiltzer L">L Wiltzer</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K Okada</name></author><author><name sortKey="Yamaoka, S" uniqKey="Yamaoka S">S Yamaoka</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author><author><name sortKey="Kuusisto, Hv" uniqKey="Kuusisto H">HV Kuusisto</name></author><author><name sortKey="Sugiyama, M" uniqKey="Sugiyama M">M Sugiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dacheux, L" uniqKey="Dacheux L">L Dacheux</name></author><author><name sortKey="Berthet, N" uniqKey="Berthet N">N Berthet</name></author><author><name sortKey="Dissard, G" uniqKey="Dissard G">G Dissard</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Delmas, O" uniqKey="Delmas O">O Delmas</name></author><author><name sortKey="Larrous, F" uniqKey="Larrous F">F Larrous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Criscuolo, A" uniqKey="Criscuolo A">A Criscuolo</name></author><author><name sortKey="Brisse, S" uniqKey="Brisse S">S Brisse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goecks, J" uniqKey="Goecks J">J Goecks</name></author><author><name sortKey="Nekrutenko, A" uniqKey="Nekrutenko A">A Nekrutenko</name></author><author><name sortKey="Taylor, J" uniqKey="Taylor J">J Taylor</name></author><author><name sortKey="Galaxy, T" uniqKey="Galaxy T">T Galaxy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blankenberg, D" uniqKey="Blankenberg D">D Blankenberg</name></author><author><name sortKey="Von Kuster, G" uniqKey="Von Kuster G">G Von Kuster</name></author><author><name sortKey="Coraor, N" uniqKey="Coraor N">N Coraor</name></author><author><name sortKey="Ananda, G" uniqKey="Ananda G">G Ananda</name></author><author><name sortKey="Lazarus, R" uniqKey="Lazarus R">R Lazarus</name></author><author><name sortKey="Mangan, M" uniqKey="Mangan M">M Mangan</name></author><author><name sortKey="Ausubel, Frederick M" uniqKey="Ausubel F">Frederick M Ausubel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giardine, B" uniqKey="Giardine B">B Giardine</name></author><author><name sortKey="Riemer, C" uniqKey="Riemer C">C Riemer</name></author><author><name sortKey="Hardison, Rc" uniqKey="Hardison R">RC Hardison</name></author><author><name sortKey="Burhans, R" uniqKey="Burhans R">R Burhans</name></author><author><name sortKey="Elnitski, L" uniqKey="Elnitski L">L Elnitski</name></author><author><name sortKey="Shah, P" uniqKey="Shah P">P Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larkin, Ma" uniqKey="Larkin M">MA Larkin</name></author><author><name sortKey="Blackshields, G" uniqKey="Blackshields G">G Blackshields</name></author><author><name sortKey="Brown, Np" uniqKey="Brown N">NP Brown</name></author><author><name sortKey="Chenna, R" uniqKey="Chenna R">R Chenna</name></author><author><name sortKey="Mcgettigan, Pa" uniqKey="Mcgettigan P">PA McGettigan</name></author><author><name sortKey="Mcwilliam, H" uniqKey="Mcwilliam H">H McWilliam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darriba, D" uniqKey="Darriba D">D Darriba</name></author><author><name sortKey="Taboada, Gl" uniqKey="Taboada G">GL Taboada</name></author><author><name sortKey="Doallo, R" uniqKey="Doallo R">R Doallo</name></author><author><name sortKey="Posada, D" uniqKey="Posada D">D Posada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name></author><author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name></author><author><name sortKey="Dufayard, Jf" uniqKey="Dufayard J">JF Dufayard</name></author><author><name sortKey="Lefort, V" uniqKey="Lefort V">V Lefort</name></author><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M Anisimova</name></author><author><name sortKey="Hordijk, W" uniqKey="Hordijk W">W Hordijk</name></author><author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M Anisimova</name></author><author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name></author><author><name sortKey="L M, C" uniqKey="L M C">C L.M.</name></author><author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minin, Vn" uniqKey="Minin V">VN Minin</name></author><author><name sortKey="Bloomquist, Ew" uniqKey="Bloomquist E">EW Bloomquist</name></author><author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gill, Ms" uniqKey="Gill M">MS Gill</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author><author><name sortKey="Faria, Nr" uniqKey="Faria N">NR Faria</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Shapiro, B" uniqKey="Shapiro B">B Shapiro</name></author><author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delport, W" uniqKey="Delport W">W Delport</name></author><author><name sortKey="Poon, Af" uniqKey="Poon A">AF Poon</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pond, Sl" uniqKey="Pond S">SL Pond</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Troupin, Cecile" sort="Troupin, Cecile" uniqKey="Troupin C" first="Cécile" last="Troupin">Cécile Troupin</name></region><name sortKey="Blanc, Herve" sort="Blanc, Herve" uniqKey="Blanc H" first="Hervé" last="Blanc">Hervé Blanc</name><name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name><name sortKey="Bourhy, Herve" sort="Bourhy, Herve" uniqKey="Bourhy H" first="Hervé" last="Bourhy">Hervé Bourhy</name><name sortKey="Dacheux, Laurent" sort="Dacheux, Laurent" uniqKey="Dacheux L" first="Laurent" last="Dacheux">Laurent Dacheux</name><name sortKey="Tanguy, Marion" sort="Tanguy, Marion" uniqKey="Tanguy M" first="Marion" last="Tanguy">Marion Tanguy</name><name sortKey="Tanguy, Marion" sort="Tanguy, Marion" uniqKey="Tanguy M" first="Marion" last="Tanguy">Marion Tanguy</name><name sortKey="Vignuzzi, Marco" sort="Vignuzzi, Marco" uniqKey="Vignuzzi M" first="Marco" last="Vignuzzi">Marco Vignuzzi</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Sabeta, Claude" sort="Sabeta, Claude" uniqKey="Sabeta C" first="Claude" last="Sabeta">Claude Sabeta</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Duchene, Sebastian" sort="Duchene, Sebastian" uniqKey="Duchene S" first="Sebastián" last="Duchene">Sebastián Duchene</name></region><name sortKey="Duchene, Sebastian" sort="Duchene, Sebastian" uniqKey="Duchene S" first="Sebastián" last="Duchene">Sebastián Duchene</name><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. 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